CORDIS Project
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This project aims to manipulate signaling in the mammalian nervous system using microbial receptor proteins. It will explore their potential in treating epilepsy and other neurological conditions by controlling neuronal electrical signals.
The goal of this project is to control signalling in the mammalian nervous system with ‘hi-jacked’ microbial receptor proteins.
We will first compile a comprehensive library of microbial ligand-gated ion channels (m-LGICs), and we will then characterize the function of selected m-LGICs in molecular detail.
In order to exploit the technological potential of m-LGICs, we will employ them to control signalling in a model of epilepsy.
This project provides the first systematic characterization of m-L…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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