CORDIS Project
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This project investigates the molecular mechanisms of MICAL enzymes, which regulate cytoskeletal dynamics and influence neuronal functions. By employing advanced imaging techniques, the research aims to clarify how MICALs are activated and how they interact with other proteins, potentially leading to new treatments for…
MICALs are a family of redox enzymes that directly bind and disassemble actin filaments.
An increasing body of evidence in recent years indicates that MICALs play essential roles in many tissues for myriad activities requiring discrete changes in the cytoskeleton, including axon guidance, cell morphology, synaptogenesis and neuronal plasticity. MICALs are a component of classical signalling pathways and are best known as effectors for semaphorin-plexin signalling.
Although the field has made eno…
UNIVERZITA KARLOVA
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