CORDIS Project
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This project explores the interactions between macrophages, immune cells, and the microbiota in the lungs using humanized mice. It aims to uncover how these interactions influence lung health and inflammation, providing insights for potential treatments.
It is poorly understood how macrophages interact with other cells and commensal microbes (microbiota) to achieve the balance between barrier immunity and tissue homeostasis in the lung.
Novel experimental systems are required to investigate the interaction between macrophages, innate lymphoid cells (ILC), and the microbiota since the immune system, inflammatory responses, and microbiota differ between mice and humans.
However, studies in humans are limited by ethical constraints.
To overcome thi…
KAROLINSKA INSTITUTET
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