CORDIS Project
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This project investigates the role of microglia in neurodevelopmental disorders like autism and Fragile X syndrome. It aims to understand how microglial function and synaptic pruning are affected in these conditions, focusing on the Integrated Stress Response pathway and the potential of targeting specific proteins for…
Neurodevelopmental disorders like autism (ASD) and Fragile X syndrome (FXS) are associated with changes in microglia function and synaptic pruning.
No approved or effective therapies exist for FXS/ASD.
Novel therapies are needed that target microglia, distinct from conventional drugs targeting neurons.
Research on synaptic pruning mediated by microglia is scarce, and the role of microglia in FXS/ASD has been overlooked.
Previous studies, including my own work and studies from the host laboratory…
FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
IDRYMA TECHNOLOGIAS KAI EREVNAS
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