CORDIS Project
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The project investigates how vitamin D influences the gut microbiome to enhance T cell-mediated immunity against cancer. It aims to identify key interactions that can improve immunotherapy outcomes by focusing on microbiome function rather than composition.
Despite unprecedented clinical success, T cell-based immunotherapies present significant heterogeneity in response rates, often attributed to dampened activation and limited tumour infiltration of CD8+ T cells.
Studies in mice and humans have shown that gut commensals can modulate anti-cancer immune responses dictating the efficacy of immunotherapy, but have failed to identify species that are consistently associated with improved patient prognosis. I recently made a breakthrough in our efforts…
THE UNIVERSITY OF MANCHESTER
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