CORDIS Project
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This project explores the role of RNA interference in the immune response of the model organism Caenorhabditis elegans to bacterial infection. It aims to identify the mechanisms by which RNA interference regulates defense gene expression during pathogen exposure.
RNA interference (RNAi) induces gene silencing and is involved in host responses to pathogens.
Faced with the bacterium Serratia (S.) marcescens, Caenorhabditis (C.) elegans responds with a behavioural response (""lawn avoidance"").
Since mutation of the RNAi gene rde-4 impairs lawn avoidance, RNAi seems to be involved. S. marcescens infection leads to upregulation of antimicrobial peptide genes in C. elegans.
Our hypothesis is that RNAi is involved in controlling this transcriptional response.…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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