CORDIS Project
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This project aims to uncover the role of microproteins in innate immune cells through a combination of computational and experimental techniques. By identifying microproteins and their interactions, it seeks to enhance understanding of immune responses and potential therapeutic targets.
Genome annotation, transcriptomic and proteomic pipelines have traditionally dismissed proteins encoded by short open reading frames (sORF) known as microproteins.
This provides a pool of unexplored functional genes.
Despite the increasing body of work in identifying the microproteome in different model organisms and cell lines, only a few have been functionally studied showing diverse regulatory roles in multiple cellular pathways.In MicroIMMUNE, I present a 3-aim workflow combining computation…
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