CORDIS Project
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This project investigates the differentiation of embryonic stem cells into mature liver cells, focusing on how nutritional changes can enhance their development. It utilizes a microdevice called the Living Cell Array to monitor transcriptional activity during this process, aiming to improve cell therapy and drug discov…
Embryonic stem cells (ESC) have a limitless capacity for self-renewal a remarkable ability to differentiate, promising a limitless source of cells for cell therapies and tissue engineering.
Organ scarcity and lack of proliferative ability makes ESC-derived hepatocytes one of the few potential sources of cells for clinical applications and pharmaceutical drug discovery.
However, current techniques for hepatocyte differentiation result in mixed cell populations, minimal metabolic function, and lon…
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