CORDIS Project
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The µSPARK project aims to develop a novel technology to study how molecular chaperones disassemble harmful protein aggregates linked to neurodegenerative diseases like Alzheimer's and Parkinson's. By utilizing advanced techniques, it seeks to enhance understanding of chaperone mechanisms at the single-molecule level.
A range of debilitating neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, arise from the formation of amyloidogenic protein aggregates.
Molecular chaperones can counteract aggregate formation, but their molecular action mechanisms remain poorly understood.
This is chiefly due to the fundamental challenge of resolving heterogeneous and dynamic aggregating protein species in the presence of chaperones.
In order to address this challenge and to advance our knowledge of ch…
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