CORDIS Project
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This project investigates the mid-blastula transition in mammalian embryos, focusing on the shift from cleavage divisions to proliferative growth. Using advanced imaging techniques, it aims to characterize cellular dynamics and identify mechanisms controlling this critical developmental stage.
Early animal embryos undergo a profound reprogramming of cell behaviour at the blastula stage in a major developmental transition known as the mid-blastula transition (MBT).
Earlier studies demonstrated that MBT is an essential transition for embryonic development across various species, involving simultaneous changes in key cellular activities: activation of zygotic genome transcription (ZGA), cell cycle elongation, loss of division synchrony, and onset of cell motility.
In contrast, little is…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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