CORDIS Project
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The project investigates how molecular mimicry affects T cell recognition of cancer antigens, using SARS-CoV-2 infection as a model. By understanding this mechanism, the project aims to enhance the selection of antigens for more effective precision T cell therapies in cancer treatment.
Scientific Challenge:
Immunotherapy has revolutionized cancer treatment, yet only a minor fraction of patients respond to frequently used immunotherapeutic treatments. T cell recognition of peptide-major histocompatibility (pMHC) class I complexes is essential to maintain immune surveillance and eliminate cancerous cells.
Numerous products of genetic and epigenetic alterations can serve as targets for T cell recognition of cancer, yet our capacity to predict what MHC-embedded targets T cells ca…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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