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The MIMoSeS project investigates how phospholipid membranes can enhance the condensation of RNA molecules, specifically G-quadruplex structures, to facilitate phase separation. This research aims to deepen our understanding of RNA biology and its implications in cellular processes and diseases.
To maintain homeostasis, cells utilize compartmentalization, traditionally achieved through membrane-bound organelles.
However, recent discoveries have highlighted the importance of membrane-less compartments, known as biomolecular condensates (BCs), which form via liquid-liquid phase separation (LLPS). BCs, rich in nucleic acids and proteins, create distinct chemical environments that regulate key metabolic processes and can be temporally controlled.
Dysregulation of BCs is linked to diseases s…
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