CORDIS Project
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This project develops a 3D organoid model of sporadic Alzheimer's disease using human-induced pluripotent stem cells and nanoparticles to mimic amyloid aggregation. By incorporating immune cells, the model aims to better understand the disease's pathology and the role of microglia in its progression, ultimately aiding…
Alzheimer’s disease (AD) is the leading cause of dementia, affecting over 50 million people worldwide.
Characterized by memory loss, cognitive decline, and the formation of amyloid-β plaques and neurofibrillary tangles, AD presents a significant global health burden.
Current AD models, particularly in mice, fail to accurately represent the sporadic form of human AD, limiting the translation of research into effective treatments.
Human-induced pluripotent stem cells (hiPSCs) offer a promising alt…
UNIVERSITY OF EASTERN FINLAND (UEF)
ITA-SUOMEN YLIOPISTO
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