CORDIS Project
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This project investigates the role of the SynGAP protein in regulating excitatory synapses, particularly in cases of genetic mutations leading to intellectual disabilities. It aims to develop strategies to restore normal synaptic function using innovative molecular tools and pharmacological approaches.
Pathogenic SYNGAP gene mutations generally lead to haploinsufficiency and account for up to 1% of intellectual disability cases.
SynGAP is one of the most abundant postsynaptic proteins that maintains a low basal activity in excitatory synapses.
It acts through AMPA type glutamate receptors (AMPAR) that mediate most fast excitatory neurotransmission in the brain.
In SynGAP haplodeficiency, AMPAR trafficking and surface expression are dysregulated, and synaptic plasticity is impaired.
In our proj…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, Bordeaux
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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