CORDIS Project
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This project aims to understand the biophysics of phagocytosis by creating a simplified model using giant unilamellar vesicles. It seeks to identify the necessary components for engulfing particles, which could inform cellular functions and lead to advancements in drug delivery systems.
The ability of cells to engulf large objects, such as invading microorganisms or apoptotic cells, is crucial to innate immunity and tissue remodelling.
The molecular basis of this process - phagocytosis - is complex, involving numerous receptors and signalling pathways.
Nevertheless, the biophysical process is always the same: the cell membrane deforms and reshapes to wrap around the particle, and upon closure and abscission of the resultant cup, the particle is internalised.
Although the key mo…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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