CORDIS Project
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This project develops a novel human induced pluripotent stem cell model to simulate localized heart attacks, enabling the study of cardiac regeneration and drug screening. By integrating a 'kill switch' and macrophages into 3D cardiac tissues, it aims to create a reliable platform for testing therapeutic compounds in c…
Cardiovascular disease remains one of the leading causes of death worldwide, with more than 4 out of 5 of these due to heart attacks.
Following a myocardial infarction (MI) the loss of cardiomyocytes (CMs) is irreparable due to their non-proliferative state.
Following a MI one of the most promising forms of recovery is using therapeutic drugs.
Since generating a new drug requires considerable amounts of money and animal testing there is a need for alternative models such as human induced pluripo…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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