CORDIS Project
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This research investigates the regulatory mechanisms controlling the maturation of microRNA-155 in macrophages, particularly in response to immune stimuli. It aims to identify components influencing miR-155 biogenesis and its role in immune responses.
MicroRNAs (miRNAs) are small non-coding RNAs which play critical roles in key biological processes, including immune response. miRNAs derive from transcripts (pri-miRNAs) which are processed by Drosha into intermediate hairpin precursors (pre-miRNAs).
Pre-miRNAs are then processed by Dicer into mature forms of about 22 nucleotides.
Mature miRNAs are loaded in the RNA-induced silencing complex (RISC) to mediate degradation and/or translation inhibition of specific target mRNAs.
Many reports docum…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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