CORDIS Project
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This project focuses on Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), aiming to identify RNA-based targets and understand the disease mechanisms in mouse models and patients. It combines research with training opportunities in molecular cardiology.
ARVC is a hereditary disease mainly characterised by the progressive substitution of the myocardium with fatty or fibro-fatty tissue involving predominantly the right ventricle.
Clinically, ARVC shows wide variation between individuals.
Together with modifier genes, common sequence variants, and environmental as well as endogenous factors, epigenetic modifiers such as miRNAs are hypothesized to be potential targets for disadvantageous environmental stimuli and may lead to the onset of complex an…
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