CORDIS Project
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This project investigates the role of Tim-3 modulation in cancer therapy, focusing on its effects on dendritic cells and the innate immune response. By employing advanced single-cell analysis and systems immunology, the research aims to enhance the effectiveness of immune-checkpoint therapies for cancer treatment.
With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe with the estimated direct health cost increasing from €79 to €86 billion during 2005-2014.
The emerging field of immune-checkpoint therapy (ICT) has demonstrated unprecedented responses in patients with several types of metastatic tumors that were previously resistant to available treatment options.
However only ~13% of patients respond to the…
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