CORDIS Project
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This project investigates how metal ions influence the structure and function of RNA molecules, particularly focusing on ribozymes and riboswitches. By utilizing advanced spectroscopy techniques, the research aims to reveal the mechanisms by which metal ions guide RNA folding and activity.
RNAs play crucial roles in cellular metabolic processes, e.g. ribozymes in RNA-processing or riboswitches in the regulation of protein expression.
Metal ions thereby guide and determine folding and function of every complex nucleic acid structure.
Recently, it has become increasingly evident that RNA folding and catalysis are extremely sensitive to changes in concentration and nature of the metal ion involved as well as to single-atom changes in metal ion complexes.
The elucidation of the specif…
University of Zurich
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