CORDIS Project
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This project investigates how cells respond to stress by activating specific signaling pathways that manage DNA damage and cell integrity. It focuses on the role of microRNAs and their regulation during oxidative stress, aiming to uncover mechanisms that control gene expression.
Cells respond to extracellular stress by inducing specific intracellular programs through the activation of stress kinase signalling pathways.
Stress responses are associated with the phosphorylation of particular substrates implicated in restoring homeostasis and cell integrity.
Oncogene activation has also been shown to generate replicative DNA damage, activate the DNA Damage Response (DDR) and thereby limit the expansion of precancerous cells.
At the molecular level, the DDR is a functional n…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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