CORDIS Project
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This project investigates how mitochondria are transported within neurons to support their function during brain development. It focuses on the role of a specific protein, Miro1, in regulating mitochondrial positioning, which is crucial for neuronal migration and may inform treatments for neurodevelopmental disorders.
Regulated trafficking of mitochondria is essential for providing ATP at the correct spatial location to power neural computation, and for providing Ca2+ buffering at sites of Ca2+ entry or release.
In neurons, the concentration of mitochondria in specific regions such as growth cones and synapses is important for correct neuronal function and development.
Consequently, defective mitochondrial trafficking is increasingly implicated in neurological diseases.
Very little is known regarding the role…
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