CORDIS Project
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The project focuses on developing synthetic D-nanobodies, which are small antibody fragments designed to bind natural targets with high affinity. By combining immunology and synthetic chemistry, it aims to enhance the properties of targeted therapeutics and imaging probes, addressing limitations of traditional monoclon…
The central role of molecularly-targeted therapeutics and imaging probes in translational research entails the development of an ever-growing arsenal of “chemical biologics” endowed with optimal in vivo properties.
In this regard, mAbs and their derivatives (e.g. ADCs) still suffer from unsettled drawbacks involving difficulties in production and characterization, leading to heterogeneous conjugates in terms of size, potency and toxicity.
Chemical modifications on mAbs are highly unreliable due…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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