CORDIS Project
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This project investigates Dravet syndrome, a severe childhood epilepsy, by exploring the role of microRNAs in regulating the transition between sodium channel isoforms. The aim is to develop a potential treatment by harnessing the protective effects of the Nav1.3 isoform through targeted miRNA manipulation in a mouse m…
Dravet syndrome (DS) is a rare epileptic encephalopathy affecting ~1:20000 children, who suffer from infantile seizures and lifelong deficits in cognitive, motor, behavioural, and social skills. DS can cause premature mortality with up to 21% of patients not reaching adulthood.
Despite the known genetic origin – 80% of patients carry a mutation in the SCN1A gene encoding the alpha1 subunit of the sodium voltage gated channel – there is no cure for this disease.
The symptoms of DS start at ~ six…
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Netherlands, Utrecht
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Denmark, Aarhus C
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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