CORDIS Project
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This project aims to generate induced hematopoietic stem cells by overexpressing specific transcription factors and microRNAs in B cells. It seeks to enhance the efficiency of stem cell reprogramming, which has significant implications for regenerative medicine.
Generating Hematopoietic Stem Cells (HSCs) by Transcription Factor (TF) overexpression is of great interest in the stem cell field and promises considerable therapeutic potential.
Among the systems described so far only one study, using murine B cells, has led to the generation of transplantable induced HSCs (iHSCs), although at exceedingly low efficiencies and using combinations between 6 and 8 TFs.
We propose here a new approach to generate iHSCs based on the use of newly identified highly pl…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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