CORDIS Project
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This project investigates the mechanisms regulating microRNA levels in the model organism Caenorhabditis elegans. It aims to understand how microRNAs are degraded or recycled, which is crucial for normal development and disease prevention, particularly in cancer.
MicroRNAs (miRNAs) are a large class of noncoding regulatory RNAs.
In animals miRNAs base-pair with the 3’ untranslated region (UTR) of their target mRNAs to target them for cleavage or translational repression.
Repressed target mRNAs accumulate in cytoplasmic structures termed P-bodies, where some targets may be degraded.
Other targets appear to be stable and can subsequently be re-expressed.
In either case, target degradation or re-expression, the fate of the repressing miRNAs remains obscure…
Novartis Forschungsstiftung
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