CORDIS Project
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This project investigates the role of macrophage migration inhibitory factor in preventing the accumulation of misfolded superoxide dismutase 1 in amyotrophic lateral sclerosis. It aims to understand how this accumulation leads to neurodegeneration and explore potential therapeutic avenues to mitigate these toxic effec…
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons.
The reason for the degeneration of motor neurons in ALS is still unknown.
Mitochondria have been implicated as a possible target for toxicity by several studies reporting a range of dysfunctions and the toxic binding of misfolded SOD1 to mitochondrial targets.
However, the mechanism by which mutant SOD1 associates with mitochondria specifically from affe…
BEN-GURION UNIVERSITY OF THE NEGEV
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