CORDIS Project
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This project explores the quality control mechanisms for mislocalized proteins, which can lead to various diseases. By studying these processes in yeast and human cells, it aims to identify the systems responsible for managing mislocalized proteins and their implications for cancer treatment.
Protein quality control systems maintain a functional proteome through detection and removal of abnormal proteins.
While typically only misfolded or damaged molecules are thought of as abnormal, recent work has revealed that also mislocalized proteins are subject to quality control.
Mislocalized proteins are defined as proteins that fail to reach their native compartment or fail to assemble into their native complex, and thus cannot function normally.
Protein mislocalization is a constitutive pr…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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