CORDIS Project
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Mismatch2model investigates DNA mismatch repair mechanisms and their role in maintaining genomic stability to prevent cancer. The project employs a systems biology approach to develop quantitative models that describe the DNA repair process across different organisms.
Mismatch2model:
Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability.
In both bacteria and eukaryotes, the loss of mismatch repair gives rise to a mutator phenotype.
In hereditary non-polyposis colon cancer (HNPCC) families, germline mutations in one MSH2, MSH6 or MLH1 allele predispose to cancer of the colon, endometrium,…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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