CORDIS Project
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The project aims to develop Clostridium leptum as a stable gut bacterium for local drug production and delivery, particularly for treating chronic intestinal diseases like colorectal cancer. It focuses on engineering this bacterium to produce natural products and incorporate biosensors for health monitoring.
Bacteria are among the most brilliant chemists on Earth.
They are capable of producing a wealth of structurally diverse natural products with a wide range of applications in medicine, such as the treatment of infections and cancer.
The synthetic production of microbial natural products and their transformation into pharmaceutical drugs is often a challenging, costly and time-consuming process due to the structural complexity of these molecules and the difficulties associated with drug solubility…
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