CORDIS Project
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This project explores the mechanisms behind tissue-specific outcomes of mitochondrial diseases. By studying mouse models and detecting protein synthesis errors, it aims to understand how these defects affect different tissues, potentially leading to new interventions for mitochondrial disorders.
Mitochondria play a central role in the energy metabolism of our bodies and their defects give rise to a large variety of clinical phenotypes that can affect practically any tissue.
The mechanisms for the tissue-specific outcomes of mitochondrial diseases are poorly understood.
Mitochondrial energy production relies on two separate protein synthesis machineries, cytoplasmic and mitochondrial, but the mechanisms regulating the concerted actions between the two are largely to be discovered.
Defect…
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