CORDIS Project
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This project aims to understand the mechanisms behind memory inflation in T cells, particularly in response to cytomegalovirus infections. It seeks to identify the cell types that sustain these immune responses to improve vaccination strategies.
T cell memory is the cornerstone of protective immunity and the key determinant of the efficacy of vaccination approaches.
Memory inflation (MI) is a unique type of CD8+ T cell memory characterized by the induction of robust and durable populations of functional effector/effector memory CD8+ T cells that is elicited by latently persistent cytomegalovirus (CMV) infections.
Accumulating evidence argues that inflationary T cells can provide exceptionally strong immune protection.
Hence, several tra…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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