CORDIS Project
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MITO-GARAGE focuses on understanding the metabolism of deoxynucleotides in mitochondrial DNA replication and its implications for mitochondrial diseases. The project aims to develop therapeutic strategies by studying specific genetic defects using advanced experimental models.
Mitochondrion is a crucial integrator of various cellular metabolic pathways in the intermediary metabolism, and it has the ability to produce oxidatively-derived energy by the oxidative phosphorylation (OxPhos) system.
The OxPhos complexes are composed of subunits encoded by both mtDNA and nuclear DNA (nDNA), and mutations in either class of genes can cause severe OxPhos defects, leading to mitochondrial diseases (MD).
Remarkably, the mitochondrion is unique among the cell's organelles, as it c…
UNIVERSIDAD DE GRANADA
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TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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