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The Mito-MechaMet project investigates how mechanical forces influence the structure of mitochondria, specifically the cristae, and how these changes affect cellular energy metabolism. By combining advanced imaging techniques and expertise in mechanobiology, the project aims to reveal the role of mitochondria in regula…
Mitochondria are double-membrane organelles that sustain the bioenergetic metabolism of cells by producing ATP at the level of the cristae, convoluted folds of the inner membrane. ATP production efficiency and mitochondrial morphology, including cristae architecture, are tightly linked.
Consequently, by being coupled to mitochondrial function, the reshaping of mitochondria across spatial scales regulates the cellular bioenergetic and metabolic states.
Mechanical stimuli have recently been shown…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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