CORDIS Project
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This project focuses on mitochondrial DNA and its role in energy production and disease. By developing genetic tools in fruit flies, it aims to manipulate and study mitochondrial mutations, enhancing our understanding of how these genetic variations affect organismal traits and health.
Mitochondrial DNA (mtDNA) is a multi-copy genome that works with the nuclear genome to control energy production and various cellular processes.
To date, disorders associated with mutations in mtDNA are among the most common genetically inherited metabolic diseases1.
However, our knowledge regarding many aspects of mtDNA biology remains limited, and we know even less about how it influences development and organismal traits.
This is largely due to our inability to manipulate mtDNA.
Recently, a c…
THE UNIVERSITY OF BIRMINGHAM
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