CORDIS Project
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This project explores the impact of beta-amyloid peptide on mitochondrial function, which is crucial in the development of Alzheimer's disease. It aims to identify molecular mechanisms linking mitochondrial dysfunction to neurodegeneration, potentially informing new therapeutic strategies.
Beta-amyloid peptide, a component of senile plaques and generated by proteolytic cleavage of the amyloid precursor protein (APP), is a key factor in the pathogenesis of Alzheimer disease (AD).
Beta-amyloid peptide has been shown to influence negatively some important mitochondrial activities such as reducing the efficiency of ATP-production via oxidative phosphorylation, enhancing mitochondrial ROS generation, and subsequently altering mitochondrial Ca2+ homeostasis.
Based on these observations,…
UNIVERSITATSKLINIKUM BONN
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