CORDIS Project
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This project investigates the formation of mitochondrial cristae, which are crucial for energy production in cells. By using advanced imaging and molecular techniques, it aims to understand how these structures develop and how mutations in mitochondrial proteins can affect their formation, potentially leading to variou…
Mitochondrial cristae biogenesis is an enigma ever since the first imaging of mitochondria, the ‘powerhouses’ of eukaryotic cells, by electron microscopy in the 1950s.
The mitochondrial cristae, dynamic and structurally conserved invaginations of the mitochondrial inner membrane, are essential for respiratory ATP generation.
Thereby, the form and function of the mitochondrial inner membrane are deeply intertwined.
Indeed, irregular or disturbed cristae morphologies are believed to cause numerous…
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
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