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The MitoEpigeNeAge project investigates how age-related neurodegeneration occurs by studying the relationship between mitochondrial clearance, epigenetic changes, and neuronal death. Using the model organism Caenorhabditis elegans, the project aims to understand how these processes affect brain aging and explore potent…
The "MitoEpigeNeAge" research proposal seeks to uncover the molecular mechanisms of age-related neurodegeneration by focusing on the interplay between mitophagy, redox-regulated histone methylation, and neuronal death.
Brain ageing is characterized by the accumulation of damaged mitochondria and epigenetic changes, leading to neurodegeneration.
Mitophagy, the process that clears damaged mitochondria, declines with age but extends lifespan and offers neuroprotection when activated.
However, its i…
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
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