CORDIS Project
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This project investigates the mechanisms of mitochondrial fusion, focusing on the role of large GTPases and the Ubiquitin-Proteasome System. By employing various scientific techniques, it aims to enhance understanding of mitochondrial dynamics and its implications for neurodegenerative diseases.
Mitochondria are not single isolated organelles but constitute a real network comparable to the Endoplasmic Reticulum or the Golgi apparatus.
In wild type conditions, this network adopts a tubular morphology that is conditioned by active and constant processes of fission and fusion of mitochondrial membranes.Unlike other organelles, fusion of mitochondrial membranes is not catalyzed by SNAREs but involves two sets of large GTPases, the mitofusins and OPA/Mgm1, involved in fusion of outer and inn…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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