CORDIS Project
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This project investigates how tumor cells disrupt the energy-producing structures in immune T cells, leading to their dysfunction in fighting cancer. By understanding these mechanisms, the project aims to restore T cell metabolic fitness and enhance their anti-tumor capabilities.
Cancer immunotherapies harnessing the tumoricidal activity of tumor-reactive T cells represent a major breakthrough in the current paradigm for treating cancer patents.
However, the highly immunosuppressive tumor microenvironments found in solid tumors present challenges by restricting the tumoricidal functions and metabolic fitness of infiltrating tumor-reactive T cells.
Given that the activation-induced metabolic switch is tightly intertwined with T cell activities, restoring the metabolic fit…
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