CORDIS Project
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This project investigates the process of mitophagy, focusing on how various factors collaborate to form mitophagosomes. By using biochemical methods, it aims to clarify the initiation and regulation of this essential cellular process, which is crucial for cell health and linked to neurodegenerative diseases like Parkin…
Mitophagy is a tightly controlled process in which dysfunctional mitochondria are isolated and selectively degraded by autophagy.
Many cell types critically rely on this pathway and mitophagy is therefore essential to life.
For instance, egg fertilization or red blood cell development would not be possible without mitophagy.
The importance of mitophagy is further underscored by its many links to human disease, most evident by mutations in the protein kinase PINK1 and the E3 ubiquitin ligase Park…
UNIVERSITAT WIEN
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