CORDIS Project
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This project investigates the role of a specific enzyme, SYNJ2, in mitochondrial biogenesis within neurons, linking lipid signaling to mitochondrial health and function. It aims to uncover mechanisms that may connect mitochondrial dysfunction to neurodegenerative and neuropsychiatric disorders, potentially leading to n…
Mitochondrial dysfunction leads to several neurodegenerative diseases and is implicated in neuropsychiatric disorders, yet our understanding of how mitochondrial biogenesis is tailored to neurons is very limited.
My identification of a role for the phosphatidylinositol-(4,5)bisphosphate (PIP2) phosphatase SYNJ2 in local mitochondrial biogenesis connects phospholipid signalling with mitochondrial maintenance and mitophagy in axons.
My lab is already utilizing advanced imaging methods to study RNA…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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