CORDIS Project
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This project investigates the mitochondrion of the malaria parasite Plasmodium falciparum, focusing on its unique membrane remodeling and energy metabolism. By employing advanced structural techniques, the research aims to elucidate the architecture of oxidative phosphorylation complexes, which are crucial for parasite…
The mitochondrion of the malaria agent Plasmodium falciparum is critical for parasite survival and a confirmed drug target.
The dynamic organelle undergoes a Plasmodium-specific membrane remodelling process to adapt to changing metabolic conditions in different hosts.
This remarkable transformation is thought to be driven by the arrangement of divergent ATP synthase and respiratory chain complexes into supramolecular assemblies, which shape the internal cristae membranes.
However, the structures…
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