CORDIS Project
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This project investigates the assembly and function of the mitochondrial repairosome, a complex responsible for repairing mitochondrial DNA damage. By understanding its composition and mechanisms, the research aims to shed light on how cells maintain genomic stability and prevent diseases related to mitochondrial dysfu…
In mammalian cells genetic information is stored in two compartments: in the nucleus and in the mitochondria. DNA in mitochondria (mtDNA), just like in theIn mammalian cells genetic information is stored in two locations: in the nucleus and in mitochondria. DNA in mitochondria, just like in the nucleus, must be faithfully copied and mistakes (i.e. mutations due to exogenous and endogenous DNA damaging agents) lead to formation of DNA lesions.
Persistence of these DNA lesions leads to genomic ins…
UNIWERSYTET GDANSKI
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