CORDIS Project
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This research investigates the mechanisms of chromosome segregation during cell division, focusing on how a phosphorylation gradient regulates nuclear envelope reformation. It aims to understand how this gradient adapts to different cell sizes using zebrafish models.
Cell division is a common process to all cell types in a multicellular organism.
During mitosis, equal chromosome segregation in anaphase is regulated by an Aurora B phosphorylation gradient, centered at the midplane between the two chromosome sets.
The gradient gives positional information that allows nuclear envelope reformation (NER) only when chromosomes are far enough from the kinase activity.
Considering the 120μm human zygote and a 15μm fibroblast, how can the gradient scale with cell siz…
UNIVERSITE DE GENEVE
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