CORDIS Project
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This project investigates Cyclophilin D as a target for selectively eliminating senescent cells, which are linked to ageing-related diseases. By utilizing CRISPR/Cas9 technology, the research aims to enhance understanding of mitochondrial functions and develop new therapeutic strategies for treating these diseases.
Ageing-related diseases are tightly correlated with the accumulation of senescent cells.
While the selective elimination of senescent cells is a primary therapeutical goal in the field, no clinically approved treatment currently exists, which constitutes an important research gap.
Abundant evidence highlights how changes in mitochondria and cellular metabolism can be both cause and consequence of the senescent phenotype and suggests a possible role of this organelle in the specific targeting of…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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