CORDIS Project
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This project investigates the role of specific proteins in mitochondrial DNA management, focusing on their function in mitochondrial movement and disease. It aims to enhance understanding of mitochondrial genetics and its implications for neurodegenerative diseases.
Mitochondrial DNA defects were established as a cause of human disease over 20 years ago, and they are increasingly recognized as a contributory factor in major causes of human morbidity, such as neurodegeneration.
Although mitochondrial DNA is known to be packaged with a variety of proteins, their functions are in many cases ill defined; hence this field is in its infancy.
The functional characterization of DNA transacting proteins in mitochondria is critical to a full understanding of mitochon…
MEDICAL RESEARCH COUNCIL
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