CORDIS Project
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This project examines the role of Mitochondrial Rho GTPases in the transport and function of mitochondria within nerve cells. By utilizing advanced imaging and genetic techniques, it seeks to uncover how these proteins influence mitochondrial dynamics and cellular signaling.
Regulated transport of mitochondria is essential for providing ATP spatio-temporaly to power nerve cell function and calcium buffering during release of neurotransmitters or post-synaptic receptor activation.
The major player of this transport machinery is Mitochondrial Rho GTPases Miro-1 and Miro-2 present at the mitochondrial outer membrane which controls binding to the Kinesin for transport along microtubules.
Miro-1 and 2 are paralogs shares ~60% homology in mammals (while nematode Caenorha…
TATA INSTITUTE OF FUNDAMENTAL RESEARCH*TIFR
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