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The MITOTUA project investigates the role of Mitofusin 2 and FATP2 in liver mitochondrial function and autophagy, particularly in the context of metabolic disorders like type 2 diabetes and non-alcoholic steatohepatitis. The research involves both in vitro and in vivo experiments to understand these interactions and th…
Hepatic mitochondrial dysfunction is a common clinical feature of several metabolic disorders, including type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH).
Mitofusin 2 (MFN2), a transmembrane protein necessary for mitochondria-endoplasmic reticulum tethering, is decreased in T2D and NASH.
Moreover, its liver-specific ablation promotes the manifestation of NASH and increases the susceptibility to developing liver cancer in mice.
Recently, the Zorzano lab has identified several intera…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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