CORDIS Project
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This project investigates the mitochondrial unfolded protein response, a cellular mechanism that helps maintain protein homeostasis under stress. It aims to identify the molecular pathways involved and their implications for aging and disease.
Cells use sensor pathways compartmentalized in subcellular organelles to recognize stress conditions, including aberrant protein folding, and in response activate gene expression programs aimed at maintaining cell survival and restoring homeostasis.
Fine-tuning of the protein-folding environment in organelles like mitochondria is important for adaptive homeostasis and may participate in development of human diseases and ageing.
Work in cultured mammalian cells and more recently in Caenorhabditis…
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